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Chronic Wasting Disease, Vet Pathol 42:530–549 (2005)

From p. 540 of Chronic Wasting Disease, Vet Pathol 42:530–549 (2005), E. S. WILLIAMS

... The origin of CWD is not known and might never be known. Three hypotheses have been suggested. Perhaps the most plausible is that CWD derives from scrapie. Support for this hypothesis comes from the moderate ability of PrPd from CWD-affected deer and elk to convert PrPc from sheep to the abnormal isoform PrPd and from comparisons of glycoform patterns on western blots of PrPd from CWD-affected deer and elk and sheep scrapie. In addition, scrapie agent inoculated intracerebrally causes a disease in elk similar to scrapie...

How sheep ranching spreads disease May 13, 2019 The Hill
... Domestic sheep were housed in an agricultural experiment station in Fort Collins, Colorado, at a time when mule deer and elk penned up in the same facility contracted the first known cases of chronic wasting disease. It soon spread throughout elk and mule deer herds in Colorado ..,

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